منابع مشابه
Intraperitoneal Therapy of Ovarian Cancer.
PURPOSE: This is a review of the rationale for the intraperitoneal administration of antineoplastic agents in the management of ovarian cancer. PATIENTS AND METHODS: Patients have been treated in a number of clinical trials to define the toxicity profile and efficacy of intraperitoneal therapy in this clinical setting. RESULTS: Phase I-II trials have confirmed that a number of cytotoxic and bio...
متن کاملFrontiers of Ovarian Cancer Therapy.
Since the majority of patients with ovarian cancer present with advanced stages of disease, more effective systemic approaches are needed to add to the benefits of surgical staging and debulking. New combinations of taxoids with cisplatin have prolonged survival, and other chemotherapeutic agents are being evaluated. Immunotherapy, including intraperitoneal approaches with monoclonal antibodies...
متن کاملOptimal treatment of early-stage ovarian cancer
BACKGROUND There is no clear consensus regarding systemic treatment of early-stage ovarian cancer (OC). Clinical trials are challenging because of the relatively low incidence and good prognosis. Initial results of the International Collaborative Ovarian Neoplasm (ICON)1 trial demonstrated benefit in both overall survival (OS) and recurrence-free survival (RFS) with adjuvant chemotherapy. We re...
متن کاملOvarian cancer gene therapy strategies
Similar to most human malignancies, ovarian cancer is a result of multiple genetic alterations. Advances in molecular biology, tumor biology, immunology, virology and other branches of science have helped in defining specific genes and molecular pathways altered in ovarian cancer. Therefore correcting these genetic alterations by gene therapy is a rational approach. Ovarian cancer is particular...
متن کاملHormone Therapy in Primary Ovarian Insufficiency
Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increa...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2016
ISSN: 0923-7534
DOI: 10.1093/annonc/mdw088